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KMID : 0376219990350020275
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Chonnam Medical Journal
1999 Volume.35 No. 2 p.275 ~ p.279
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The Effects of Sulodexide(Oral Heparin) in Coronary Stented Patients
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Jeong Myung-Ho
Ahn Young-Keun
Park Jong-Chun
Kang Jung-Chaee
Bom Hee-Seung
Kim Nam-Ho
Park Woo-Suck
Kim Jun-Woo
Kim Sung-Hee
Cho Jang-Hyun
Cho Jeong-Gwan
Park Chang-Min
Cho Dong-Hyeok
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Abstract
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The purpose of this study was to determine the long-term clinical efficacy and safety of sulodexide on coronary stented patients. From October 1997, 137 patients who had underwent coronary stent implantation and taken a sulodexide (oral heparin: Vesseldue ) 450 LRU (lipoprotein-lipase-releasing unit) 3 capsules per day orally for 1 to 6 months were included and compared with control group, in which follow-up coronary angiography was done among stented patients not treated which sulodexide, during the same period as sulodexide treated group. Combinated antiplatelet agents were limited to aspirin and ticlopidine, or aspirin and cilostazol. During follow-up, there were no significant bleeding complications or specific side effects. Prothrombin time and activated partial thrombonplastin time was not changed. Acute or subacute stent(PT) thrombosis was observed in 3 patients(APTT) (2.1%), but fatal myocardial infractions or deaths were not appeared. Among 52 patients who underwent follow-up coronary angiography, significant stent restenosis was developed in 12 patients (23.1%). In conclusion, sulodexide combined with antiplatelet agents is safe and effective in preventing the acute and subacute thrombosis. Further study is necessary to document the effect of sulodexide in preventing restenosis.
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KEYWORD
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Stent, Oral Heparin
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